Aktivita cytochromu P4502D6 při dlouhodobé léčbě paroxetinem ve srovnání se zdravými dobrovolníky

• Title in English: CYP2D6 activity in patients long-term treated with paroxetine and comparison with healthy volunteers
• Authors: ŽOURKOVÁ Alexandra; JUŘICA Jan; SLANAŘ Oldřich; VEČEŘOVÁ Monika
• Year of publication: 2009
• Type: Article in Periodical
• Magazine / Source: Psychiatrie časopis pro moderní psychiatrii
• MU Faculty or unit: Faculty of Medicine
• Field: Psychiatry, sexuology
• Keywords: CYP2D6; phenotype; paroxetine
• Description: Totally 56 patients with depressive or anxiety disorder treated with paroxetine were enrolled into the study. Age-, and sex-matched control group was created from 56 volunteers. The aim of our study war to evaluate into which extent is CYP2D6 phenotype affected by paroxetine treatment in relation to CYP2D6 genotype. Paroxetine treatment leads to a hyghly significant reduction of CYP2D6 activity in subject genotyped as wild-type EMs.

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