Levels of angiogenic factors in patients with multiple myeloma correlate with treatment response

• Authors: POUR Luděk; ŠVÁCHOVÁ Hana; ADAM Zdeněk; ALMÁŠI Martina; BUREŠOVÁ Ivana; BÜCHLER Tomáš; KOVÁŘOVÁ Lucie; NĚMEC Pavel; PENKA Miroslav; VORLÍČEK Jiří; HÁJEK Roman
• Year of publication: 2010
• Type: Article in Periodical
• Magazine / Source: Annals of Hematology
• MU Faculty or unit: Faculty of Medicine
• Field: Oncology and hematology
• Keywords: multiple myeloma; angiogenesis; cytokines
• Description: Angiogenesis plays a significant role in the pathogenesis of multiple myeloma (MM). We have measured concentrations of angiogenesis activators, including vascular endothelial growth factor (VEGF), basic fibroblast growth factor, and hepatocyte growth factor (HGF), and inhibitors, including endostatin, thrombospondin-1 (TSP-1), and angiostatin in the peripheral and bone marrow blood of MM patients at diagnosis and after high-dose chemotherapy.

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