MDMA decreases sociability and aggression and increases anxiety in mouse model of agonistic behaviour

• Authors: ŠLAIS Karel; LANDA Leoš; ŠULCOVÁ Alexandra
• Year of publication: 2009
• Type: Article in Periodical
• Magazine / Source: Activitas Nervosa Superior Rediviva
• MU Faculty or unit: Faculty of Medicine
• Field: Pharmacology and pharmaceutical chemistry
• Keywords: MDMA; aggressivity; sociability; anxiety; agonistic behaviour
• Description: We evaluated acute effects of methylen-dioxy-methamphetamine (MDMA) on agonistic behaviour in singly-housed mice on paired conflict interactions with group-housed partners. We fully confirmed the antiaggressive effects and increase of defensive-escape behaviour in aggressive mice. The analysis of timid mice brought evidence of anxiogenic effect of MDMA.

Related projects

• The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.