Prediction of localization and interactions of apoptotic proteins

• Authors: VAŘECHA Miroslav; ULMAN Vladimír; MATULA Pavel; KOZUBEK Michal
• Year of publication: 2009
• Type: Conference abstract
• MU Faculty or unit: Faculty of Informatics
• Description: We found the AMID protein to be cytoplasmic, most probably incorporated into the cytoplasmic side of the lipid membranes. Bioinformatic predictions were conducted to analyze the interactions of the studied proteins with each other and with other possible partners. We conducted molecular modeling of proteins with unknown 3D structures. These models were then refined by MolProbity server and employed in molecular docking simulations of interactions. Our results show data acquired using a combination of modern in silico methods and image analysis to understand the localization, interactions and functions of proteins AMID, AIF, endonuclease G, and other apoptosis-related proteins.

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