Novel fucose binding lectin domain from the human pathogen Bukholderia cenocepacia

• Authors: ŠULÁK Ondřej; CIOCI Gianluca; DELIA Monia; IMBERTY Imberty; WIMMEROVÁ Michaela
• Year of publication: 2009
• Type: Article in Proceedings
• Conference: Glycoconjugate Journal
• MU Faculty or unit: Faculty of Science
• Field: Biochemistry
• Keywords: Superlectin; X ray; Isothermal titration callorimetry; Burkolderia cenocepacia
• Description: The contribution is focused on the BclC lectin that displays affinity for both fucosylated and mannosylated saccharides. Separate cloning of N- and C terminal parts of the protein showed that while C-terminal part, which is homologous to PA-IIL, displays narrow specificity for mannosylated oligosaccharides, N-terminal part represent a novel lectin domain with strict specificity towards fucosylated oligosaccharides.

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