Publication details
CORD: Comparison of Recommended Doses of ace inhibitors and angiotensin II receptor blockers
| Authors | |
|---|---|
| Year of publication | 2009 |
| Type | Article in Periodical |
| Magazine / Source | International Journal of Cardiology |
| MU Faculty or unit | |
| Citation | |
| Field | Cardiovascular diseases incl. cardiosurgery |
| Keywords | Hypertension; Losartan; Ramipril; Cough |
| Description | The CORD trials tested ramipril and losartan in patients with hypertension. CORD A randomised 4016 patients with blood pressure (BP) < 160/100 mm Hg, who had been treated with an ACEI for > 3 months. The patients discontinued ACEI and switched to losartan. After 1 month the BP decreased to 7.7/4.7 mm Hg (p < 0.001) and after 1 year to 13.8/8.7 mm Hg (p < 0.001). CORD B compared ramipril and losartan in 3813 patients with hypertension who were not being treated with an ACEI or ARB. The patients were randomised to ramipril (n = 1926) or losartan (n = 1887). After 1 year the BP decreased in the ramipril group to 21.8/13.7 mm Hg (p < 0.001) and in the losartan group to 22.0/13.3 mm Hg (p < 0.001). No significant differences were found between the groups. No differences were in serious adverse events. Dry cough was more frequently after ramipril (33 vs 4, p < 0.001). |
| Related projects: |