Negative prognostic significance of two or more cytogenetic abnormalities in multiple myeloma patients treated with autologous stem cell transplantation

• Authors: GREŠLIKOVÁ Henrieta; ZAORALOVÁ Romana; FILKOVÁ Hana; NĚMEC Pavel; OLTOVÁ Alexandra; KUPSKÁ Renata; RUDOLECKÁ Petra; SMETANA Jan; POUR Luděk; ZAHRADOVÁ Lenka; KREJČÍ Marta; BÜCHLER Tomáš; ADAM Zdeněk; HÁJEK Roman; KUGLÍK Petr
• Year of publication: 2010
• Type: Article in Periodical
• Magazine / Source: Neoplasma
• MU Faculty or unit: Faculty of Medicine
• Field: Oncology and hematology
• Keywords: multiple myeloma; cytogenetics;FISH;chromosomal abnormalities;transplantation;chemotherapy.
• Description: Malignant plasma cells in multiple myeloma (MM) are frequently characterized by complex karyotypes and chromosome instability. These cytogenetic changes are considered important prognostic indicators in MM patients. We have studied samples from 68 patients with newly diagnosed MM who were treated with high-dose chemotherapy and autologous stem cell transplantation. Our results show a high incidence of chromosomal abnormalities in MM patients and confirm the prognostic impact of selected chromosomal aberrations as well as cumulative effect of multiple cytogenetic changes occurring simultaneously.

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