Publication details

Study the N-acetylglucosaminyltransferase V structure through homology modeling methods.

Authors

KOZMON Stanislav TVAROŠKA Igor

Year of publication 2009
Type Conference abstract
MU Faculty or unit

Faculty of Science

Citation
Description In the present study, we have attempted to build model of the GnT-V 3D-structure. We obtain altogether 10 models of the GnT-V structure. On the basis of the 3D-structure analysis we have chosen five models for the molecular dynamic equilibration in water. All structure models have been equilibrated at 300 K during 4ns. The molecular dynamic simulation show, that more reliable model might be the model based on the MurG template. Due to these result we did multiple sequence alignment with another seven members of this family, including MurG, to observe more precise alignment. In addition we also took one glycosyltransferase, which family has not been specified yet, a-1,6-fucosyltransferase FUT8 (2DE0).

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