Inhibition of gap-junctional intercellular communication and activation of mitogen-activated protein kinases by cyanobacterial extracts - Indications of novel tumor-promoting cyanotoxins?

• Authors: BLÁHA Luděk; BABICA Pavel; HILSCHEROVÁ Klára; UPHAM B.
• Year of publication: 2010
• Type: Article in Periodical
• Magazine / Source: Toxicon
• MU Faculty or unit: Faculty of Science
• Doi: http://dx.doi.org/10.1016/j.toxicon.2009.07.009
• Field: Environment influence on health
• Keywords: GJIC; MAPK; cyanobacteria
• Description: Extracts of cyanobacteria (laboratory cultures of Microcystis aeruginosa and Aphanizomenon flos-aquae and water blooms dominated by these species) inhibited GJIC and activated MAPKs in a dose-dependent manner (effective concentrations ranging 0.5-5 mg d.w./mL). Effects were independent of the microcystin content and the strongest responses were elicited by the extracts of Aphanizomenon sp.

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