Production of immune-modulatory nonclassical molecules HLA-G and HLA-E by tumor infiltrating ameboid microglia/macrophages in glioblastomas: A role in innate immunity?

• Authors: KŘEN Leoš; MÚČKOVÁ Katarína; LŽIČAŘOVÁ Eva; SOVA Marek; VYBÍHAL Václav; SVOBODA Tomáš; FADRUS Pavel; SMRČKA Martin; SLABÝ Ondřej; LAKOMÝ Radek; VAŇHARA Petr; KŘENOVÁ Zdenka; MICHÁLEK Jaroslav
• Year of publication: 2010
• Type: Article in Periodical
• Magazine / Source: Journal of Neuroimmunology
• MU Faculty or unit: Faculty of Medicine
• Doi: http://dx.doi.org/10.1016/j.jneuroim.2010.01.014
• Field: Neurology, neurosurgery, neurosciences
• Keywords: HLA-E; HLA-G; Microglia; Glioblastoma
• Description: The possible role of immune-modulatory nonclassical molecules HLA-G and HLA-E in an anti-tumoral response and development of glioblastoma is not well characterized. In this study, we evaluated an expression of HLA-G and HLA-E by activated tumor infiltrating microglia/macrophages. We found production of FILA-G and HLA-E by tumor infiltrating activated microglia/macrophages in a majority of glioblastomas. We speculate that the expression of these molecules by activated microglia/CNS macrophages plays a role in the anti-tumoral immunity in the development of glioblastoma. Mechanisms of microglia-glioblastoma cell interactions with respect to the expression of these molecules deserves further study.