Publication details
Expression cloning of lysis genes from polyvalent staphylococcal bacteriophage
| Authors | |
|---|---|
| Year of publication | 2010 |
| Type | Article in Proceedings |
| Conference | The student scientific conference on genetically modified organisms |
| MU Faculty or unit | |
| Citation | |
| Web | http://www.biomania.cz/udalosti-a-akce/studentska-vedecka-konference-pro-studenty-pracujici-s-geneticky-modifikovanymi-organismy-gmo/ |
| Field | Genetics and molecular biology |
| Keywords | bacteriophages; lytic enzymes; Stphylococcus; protein preparation |
| Description | The increasing number of pathogenic bacteria resistant to antimicrobial agents is a serious public health problem. Phage therapy appears to be a suitable alternative to antibiotics treatment. In history, it was envisaged to use bacteriophages as antimicrobial agents, but currently the research focus on phage encoded antimicrobial proteins. Endolysins are phage lytic proteins which digest the cell wall of bacteria. Here we report expression of the genes encoding lytic proteins from bacteriophage 812. These enzymes lyse cells of Staphylococcus aureus and could have practical use in phage therapy. |
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