Publication details
Laboratory for Cell Biology of Human Pathogenic Yeasts
| Authors | |
|---|---|
| Year of publication | 2010 |
| Type | Chapter of a book |
| MU Faculty or unit | |
| Citation | |
| Description | Our recent research identified cytoskeleton in Cryptococcus neoformans, Aureobasidium pullulans, Fellomyces fuzhouensis, Cryptococcus laurentii and Malassezia pachydermatis.The cytoskeleton is involved in budding, bud-fission, hyphal growth and conidiogenesis of human yeast and fungal pathogens. The cytoskeleton was investigated as a potential target of inhibition using microtubule and actin inhibitors. All microtubule inhibitors were effective, while clinical ones had only transient effect and resistant cells originated. Cytochalasins were not effective. Latrunculin A inhibited budding, fission, hyphal growth and conidiogenesis. The most efficient inhibition was reached by combining the microtubule and actin inhibitors(Kopecká M.,Gabriel M., Chemotherapy 2009;55:278-286). Our study brought new findings of the basic research on the cytoskeleton as a new target for inhibition of yeast human pathogens, which may show the way to a new antifungal strategy. |
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