Generation of myeloma-specific T cells using dendritic cells loaded with MUC1- and hTERT- drived nonapeptides or myeloma cell apoptotic bodies

• Authors: OČADLÍKOVÁ Darina; KRYUKOV Fedor; MOLLOVÁ Klára; KOVÁŘOVÁ Lucie; BUREŠOVÁ Ivana; MATĚJKOVÁ Eva; PENKA Miroslav; BÜCHLER Tomáš; HÁJEK Roman; MICHÁLEK Jaroslav
• Year of publication: 2010
• Type: Article in Periodical
• Magazine / Source: Neoplasma
• MU Faculty or unit: Faculty of Medicine
• Field: Oncology and hematology
• Keywords: multiple myeloma; dendritic cells; immunotherapy; hTERT; MUC1; apoptotic bodies
• Description: The aim of our study was to generate myeloma-specific cytotoxic T lymphocytes in vitro using dendritic cells loaded with peptide antigens or apoptotic bodies. We present a method for the priming and expansion of myeloma-specific T lymphocytes using dendritic cells loaded with different types of tumor antigens. Cytotoxic T lymphocytes and/or activated dendritic cells generated by the described methods can be applied for cellular immunotherapy against multiple myeloma and other malignancies.

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