Clotting factors and eicosanoids protect against nematode infections

• Authors: HYRŠL Pavel; DOBEŠ Pavel; WANG Zhi; HAULING Thomas; WILHELMSSON Christine; THEOPOLD Ulrich
• Year of publication: 2011
• Type: Article in Periodical
• Magazine / Source: Journal of Innate Immunity
• MU Faculty or unit: Faculty of Science
• Field: Immunology
• Keywords: Drosophila melanogaster; eicosanoids; entomopathogenic nematodes; Heterorhabditis bacteriophora; transglutaminase; coagulation; Photorhabdus luminescens
• Description: We show that hemolymph clotting protects Drosophila melanogaster against infections with an entomopathogenic nematode and its symbiotic bacterium. We also provide biochemical and genetic evidence for an involvement of eicosanoids in the same infection model. Taken together our results confirm the conserved nature of the immune function of clot formation.

Related projects

• The influence of the eicosanoid biosynthesis inhibitors to immunity of the wax moth Galleria mellonella