Publication details
Structural Dynamics of the Box C/D RNA Kink-Turn and Its Complex with Proteins: The Role of the A-Minor 0 Interaction, Long-Residency Water Bridges, and Structural Ion-Binding Sites Revealed by Molecular Simulations
| Authors | |
|---|---|
| Year of publication | 2010 |
| Type | Article in Periodical |
| Magazine / Source | Jouranl of Physical Chemistry B |
| MU Faculty or unit | |
| Citation | |
| Field | Biophysics |
| Keywords | RNA-protein complex; molecular dynamics; kink-turn; A-minor interaction |
| Description | The study is focused on investigation of Box C/D RNA Kink-Turn with two proteins: native archaeal L7ae protein and human 15.5 kDa protein. The simulations reveal structural details of the studied molecules on nanosecond time scale, i.e. structural dynamics of essential tertiary interaction within kink-turn, reduced kink-turn flexibility upon protein binding, structurally important water molecules and ion binding sites. |
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