Publication details
Zinek a jeho vztah k nádorům prostaty
| Title in English | Zinc and its relation to prostate tumours |
|---|---|
| Authors | |
| Year of publication | 2010 |
| Type | Article in Periodical |
| Magazine / Source | Praktický lékař |
| MU Faculty or unit | |
| Citation | |
| Web | http://www.prolekare.cz/prakticky-lekar-clanek?id=32567 |
| Field | Oncology and hematology |
| Keywords | zinc;metallothionein;thiols;resistance;tumour disease |
| Description | Zinc ions (Zn2+) are essential elements necessary for the normal function of mammalian cells. They participate in the regulation of the immune system, gene expression, energy metabolism, signal transduction and perform a structural function. However, an increased level of these ions is toxic, and so needs to be controlled. This control is primarily carried out by zinc transporters and zinc-binding proteins, in particular, metallothioneins. Prostatic tissue is very specific in Zn2+metabolism. Its cells accumulate a greater quantity of these ions (up to ten times more). Prostate cancer, a common cancer of men, is characterized by diverse and not very clear mechanisms, which serve to maintain Zn2+ levels. This unusual metabolism of Zn2+ has two important implications: -participation in the pathogenesis of the disease (due to apoptosis) and - increased serum levels of metallothioneins (with potential use of these proteins as markers for this disease). |
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