Structural basis of the affinity for oligomannosides and analogs displayed by BC2L-A, a Burkholderia cenocepacia soluble lectin

• Authors: LAMEIGNERE Emilie; SHIAO Tze Chieh; ROY Rene; WIMMEROVÁ Michaela; DUBREUIL Fréderic; VARROT Annabelle; IMBERTY Anne
• Year of publication: 2010
• Type: Article in Periodical
• Magazine / Source: Glycobiology
• MU Faculty or unit: Faculty of Science
• Doi: http://dx.doi.org/10.1093/glycob/cwp151
• Field: Biophysics
• Keywords: bacterial lectin;Burkholderia cenocepacia;mannose;oligosaccharides
• Description: The disaccharides and the trisaccharide,Man1-3(Man1-6)Man were tested by titration microcalorimetry in order to evaluate their affinity for BC2L-A in solution and to characterize the thermodynamics of the binding. Oligomannose analogs presenting two mannoside residues separated by either flexible or rigid spacer where also tested.

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