Publication details

Studie CORD - analýza nemocných starších 80 let a nemocných s izolovanou systolickou hypertenzí

Title in English CORD study - an analysis of patients aged 80 years and patients with isolated systolic hypertension
Authors

ŠPINAR Jindřich VÍTOVEC Jiří SOUČEK Miroslav DUŠEK Ladislav PAVLÍK Tomáš

Year of publication 2010
Type Article in Periodical
Magazine / Source Kardiologická revue
MU Faculty or unit

Faculty of Medicine

Citation
Field Cardiovascular diseases incl. cardiosurgery
Keywords Losartan; Ramipril; Systolic Hypertension; Older Age
Description The CORD study - COmparison of Recommended Doses - was one of the largest Czech Republic-based clinical studies in hypertension. The study involved 585 centres and 11,284 screened patients, out of which 11,284 were randomised into the CORD A or CORD B study. The effect observed in patients above the age of 80 was the same as in patients under 80 years of age; we did not identify any difference in the reduction of blood pressure or in the incidence of adverse events, including renal functions. Patients with isolated systolic hypertension differed from the others particularly with respect to the effects on diastolic blood pressure that was only marginally reduced while the reduction of systolic pressure was comparable to patients with systolic-diastolic hypertension. This observation was highly statistically significant. In patients with isolated systolic hypertension, losartan was more effective than ramipril in reducing systolic blood pressure (p = 0.02), while both agents produced equal reduction of diastolic blood pressure.
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