Publication details
Base pair stacking in nucleosome DNA and bendability sequence pattern
| Authors | |
|---|---|
| Year of publication | 2010 |
| Type | Article in Periodical |
| Magazine / Source | JOURNAL OF THEORETICAL BIOLOGY |
| MU Faculty or unit | |
| Citation | |
| Field | Genetics and molecular biology |
| Keywords | Chromatin; Chromatin code; DNA deformation; DNA minor grooves; Nucleosome DNA sequence; Nucleosome positioning |
| Description | DNA deformation in the nucleosome involves partial unstacking between bases and base pairs. By adjusting orientations of different base-pair stacks relative to the histone octamer surface, the optimal set of stacks and their positions is derived, resulting in a sequence pattern, theoretically best suitable for nucleosome DNA. The sequence is very much consistent with available experimental data, thus, suggesting a common eukaryotic nucleosome DNA bendability sequence pattern based exclusively on the very basics of DNA. (C) 2009 Elsevier Ltd. All rights reserved. |
| Related projects: |