Publication details
Meduloblastom: nejčastější zhoubný nádor mozku u dětí.
| Authors | |
|---|---|
| Year of publication | 2010 |
| Type | Article in Periodical |
| Magazine / Source | Onkologie |
| MU Faculty or unit | |
| Citation | |
| Field | Oncology and hematology |
| Keywords | medulloblastoma; children; prognosis; radiotherapy; chemotherapy |
| Description | Medulloblastoma, an embryonal neuroectodermal tumor of the cerebellum, is the most common form of malignant brain tumor of childhood. 10–12 new cases occur in the Czech Republic each year. Current treatment, which combines modern techniques of neurosurgical resection and radiotherapy, and adjuvant chemotherapy, has improved survival substantially. The intensity of multimodal therapy is based on clinical criteria of age, metastatic disease and the extent of surgical resection. Nevertheless, 19–30 % of average risk and 30–70 % of high risk patients experience relapses within 5 years from initial presentation. Identification of biological prognostic markers and cellular targets will result in risk-adapted treatment, which is crucial for improving cure rates and reducing long-term sequelae. |