Publication details
Nutnost posunu BCG vakcinace - poučení z komlikací a úmrtí dětí s vrozenými imunodeficiencemi
| Title in English | Necessity to postpone BCG vaccination - a lesson from complicationes and deaths in children with primary immunodeficiencies |
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| Authors | |
| Year of publication | 2010 |
| Type | Article in Periodical |
| Magazine / Source | Studia pneumologica et phtiseologica |
| MU Faculty or unit | |
| Citation | |
| Field | Immunology |
| Keywords | BCG; primary immunodeficiencies; SCID; BCGosis; immunization; interaction of vaccines |
| Description | The only available vaccine against tuberculosis is the BCG. The BCG vaccines, live attenuated strains of Mycobacterium bovis, were considered to be safe in the immunocompetent host. They are usually administered within the first few days of life as a part of community health program. Nevertheless, profoundly immunocompromised patients may develop disseminated BCG infection after vaccination. For this reason, the BCG vaccine given early after birth became unacceptable. The new immunization schedule is needed. We recommend a change of current practice of BCG vaccination considering new immunization schedule with hexavalent vaccine. We advise to postpone BCG vaccination until the second half of the child's first year of life which is in accordance with WHO. |
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