Publication details
Intrakraniální nádory – diagnostika a terapie
| Title in English | Intracranial tumors: diagnosis and treatment |
|---|---|
| Authors | |
| Year of publication | 2010 |
| Type | Article in Periodical |
| Magazine / Source | Interní medicína pro praxi |
| MU Faculty or unit | |
| Citation | |
| Field | Other specializations of internal medicine |
| Keywords | brain tumors; surgery; stereotactic biopsy; immunochemistry; radiation therapy; chemotherapy |
| Description | Primary malignant brain tumors account for only 2 % of all adult cancers but they cause a disproportionately high cancer-related disability and death. Primary brain tumors according the WHO classification are classified based on their cellular origin and histological appearance. In this review, we describe the standard treatment modalities for malignant and benign brain tumors, which include surgery, radiation therapy and chemotherapy, as well as the status of novel therapies that have been developed to target various aspects of glioma cell biology. Common presenting symptoms include headache, seizures, and altered mental status. Magnetic resonance imaging is the preferred initial imaging study and the stereotactic biopsy is often required to confirm the diagnosis. Treatment depends on the histological diagnosis. Surgical resection of the tumor is the mainstay of therapy. Postoperative radiation and chemotherapy have improved survival in patients with highgrade brain tumors. Recent developments in targeted chemotherapy provide novel treatment options for patients with tumor recurrence. Benign tumors and metastases are usually curable with surgical resection or radiation therapy including stereotactic radiation. |