Amisulpride therapeutic dose-induced asymptomatic bradycardia

• Authors: PŘIKRYL Radovan; USTOHAL Libor; PŘIKRYLOVÁ KUČEROVÁ Hana
• Year of publication: 2011
• Type: Article in Periodical
• Magazine / Source: Progress in Neuro-Psychopharmacology & Biological Psychiatry
• MU Faculty or unit: Faculty of Medicine
• Doi: http://dx.doi.org/10.1016/j.pnpbp.2010.10.006
• Field: Psychiatry, sexuology
• Keywords: amisulpride; bradycardie; cause
• Description: Severe cardiac problems including QTC prolongation, bradycardia, and cardiac rhythm disorders, including Torsade de pointes, have been repeatedly described in cases of amisulpride overdose. Another case involving cardiac problems during amisulpride therapy was described with concomitant hypocalaemia. Amisulpride overdose, drug interactions, or abnormal electrolyte serum levels did not occur in the case of our patient. Although bradycardia is a very rare complication of amisulpride therapy and is often asymptomatic, psychiatrists need to be aware of it.

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