Publication details
Discovery of pyrazolo[1,5-a]pyrimidine-based CHK1 inhibitors: A template-based approach-Part 1.
| Authors | |
|---|---|
| Year of publication | 2011 |
| Type | Article in Periodical |
| Magazine / Source | Bioorganic & Medicinal Chemistry Letters |
| MU Faculty or unit | |
| Citation | |
| Field | Organic chemistry |
| Keywords | Kinase CHK1 Pyrazolo[1 5-a]pyrimidine Template |
| Description | The synthesis and hit-to-lead SAR development of a pyrazolo[1,5-a]pyrimidine hit 4 is described leading to a series of potent, selective CHK1 inhibitors such as compound 17r. In the Letter, the further utility of the pyrazolo[1,5-a]pyrimidine template for the development of potent, selective kinase inhibitors is detailed. |