Standardised uptake value of 18F-FDG on staging PET CT in newly diagnosed patients with different subtypes of non-Hodgkin’s lymphoma

• Authors: PAPAJÍK Tomáš; MYSLIVEČEK Miroslav; ŠEDOVÁ Zuzana; BURIÁNKOVÁ Eva; PROCHÁZKA Vít; KORANDA Pavel; RAJDA Luděk; KUBOVÁ Zuzana; PALOVÁ Miroslava; KUČEROVÁ Ladislava; FLODR Patrik; JARKOVSKÝ Jiří; DUŠEK Ladislav; INDRÁK Karel
• Year of publication: 2011
• Type: Article in Periodical
• Magazine / Source: European Journal of Haematology
• MU Faculty or unit: Faculty of Medicine
• Doi: http://dx.doi.org/10.1111/j.1600-0609.2010.01532.x
• Field: Oncology and hematology
• Keywords: non-Hodgkin’s lymphoma; positron emission tomography; computed tomography; standardised uptake value
• Description: Objectives: Positron emission tomography using 2-[fluorine-18]-fluoro-2-deoxy-D-glucose (18F-FDG) is considered to be the most beneficial imaging method for staging patients with non-Hodgkin’s lymphoma (NHL). The intensity of 18F-FDG accumulation may be determined by calculating the so-called standardised uptake value (SUV). The study aimed at assessing the benefit of SUVmax determination in staging 18F-FDG PET CT in untreated patients with NHL. Methods: One hundred and forty-nine initial staging 18F-FDG PET CT scans performed in patients with NHL between January 2007 and August 2009 were assessed, and the SUVmax was determined. Results: The highest mean and median values of SUVmax were observed in patients with diffuse large B-cell lymphoma (DLBCL), the lowest mean and median values were found in small lymphocytic lymphoma. The overlap in SUVmax lt; 10 between DLBCL and the other subgroups of NHL was very significant. Statistically, no correlation was found between the lactate dehydrogenase and SUVmax values. On the other hand, a correlation of the Ki-67 proliferative index of tumour cells and SUVmax was revealed (r = 0.409, P lt; 0.001). The geometric mean of SUVmax in patients with Ki-67 60 and those with Ki-67 gt; 60 was 8.8 and 14.3, respectively (P lt; 0.001). Conclusions: The results confirm that SUVmax is not beneficial for making a more precise diagnosis in most patients with NHL. Correlation of SUVmax with the Ki-67 values suggests that SUVmax might have a prognostic values in NHL.