Polymorphisms Contribution to the Determination of Significant Risk of Specific Toxicities in Multiple Myeloma

• Authors: ALMÁŠI Martina; ŠEVČÍKOVÁ Sabina; ŠVÁCHOVÁ Hana; SÁBLÍKOVÁ Barbora; MÁJKOVÁ Petra; HÁJEK Roman
• Year of publication: 2011
• Type: Article in Periodical
• Magazine / Source: Klinická onkologie
• MU Faculty or unit: Faculty of Medicine
• Field: Oncology and hematology
• Keywords: single nucleotide polymorphisms (SNPs); genotyping; real-time PCR; allelic discrimination; toxicity; multiple myeloma
• Description: The introduction of new drugs improved clinical response of patients with diagnosed multiple myeloma (MM); however, MM is still an incurable disease that leads to frequent relapses. Individual genetic variability can significantly affect therapeutic response, sensitivity and toxicity. Analysis of single nucleotide polymorphisms (SNPs) to study genetic changes is the genomic method that can obtain information for improving the effectiveness of treatment with minimum undesirable toxicity followed by individual treatments. The aim of this paper is to explain the possibility of detection and evaluation of polymorphisms associated with toxicity of treatment in patients with MM.

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