Visualization of Numerical Centrosomal Abnormalities by Immunofluorescent Staining

• Authors: KRYUKOV Fedor; DEMENTYEVA Elena Vladimirovna; KUGLÍK Petr; HÁJEK Roman
• Year of publication: 2011
• Type: Article in Periodical
• Magazine / Source: Klinická onkologie
• MU Faculty or unit: Faculty of Medicine
• Field: Oncology and hematology
• Keywords: multiple myeloma; B cells; centrosome amplification; plasma cells
• Description: The presence of multiple centrosomes in tumor cells is associated with the formation of multipolar mitotic spindles and results in aneuploidy of both daughter cells. Centrosome amplification is a feature of all cancer cells. We have previously described centrosome amplification in abnormal B cells. Further studies of centrosome amplification in different stages of B lineage development could provide important information about multiple myeloma pathogenesis.

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