Impact of Nestin Analysis in Multiple Myeloma

• Authors: ŠVÁCHOVÁ Hana; KOVÁŘOVÁ Lucie; ŠTOSSOVÁ Jana; POTÁČOVÁ Anna; POUR Luděk; HÁJEK Roman
• Year of publication: 2011
• Type: Article in Periodical
• Magazine / Source: Klinická onkologie
• MU Faculty or unit: Faculty of Medicine
• Field: Oncology and hematology
• Keywords: nestin; plasma cells; multiple myeloma; myeloma stem cells; myeloma-initiating cells; flow cytometry
• Description: Nestin, a marker of multipotent precursor cells, is an important dynamic structure; its polymerization/ depolymerization influences intracellular signaling and participates in key cell processes such as proliferation, migration and cell survival. It is presumed that nestin plays a central role in carcinogenesis. It is suggested that nestin might be a suitable diagnostic and prognostic indicator of malignancy and a potential marker of cancer stem cells. Unexpectedly, nestin has been identified in mature CD138+CD38+ plasma cells (PC) of multiple myeloma patients (MM). Expression of nestin, a marker of stem/progenitor cells, in malignant PC, that are considered to be terminally differentiated, indicates that nestin might play a unique role in pathology of MM.

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