MYB transcriptionally regulates the miR-155 host gene in chronic lymphocytic leukemia

• Authors: VARGOVÁ Karin; CURIK Nikola; BURDA Pavel; BAŠOVÁ Petra; KULVAIT Vojtěch; POSPÍŠIL Vít; SAVVULIDI Filipp; KOKAVEC Juraj; NEČAS Emanuel; BERKOVÁ Adéla; OBRTLÍKOVÁ Petra; KARBAN Josef; MRÁZ Marek; POSPÍŠILOVÁ Šárka; MAYER Jiří; TRNĚNÝ Marek; ZAVADIL Jiří; STOPKA Tomáš
• Year of publication: 2011
• Type: Article in Periodical
• Magazine / Source: Blood
• MU Faculty or unit: Central European Institute of Technology
• Doi: http://dx.doi.org/10.1182/blood-2010-05-285064
• Field: Oncology and hematology
• Keywords: MYB; CLL; miR-155 host gene; B-CLL
• Description: Elevated levels of microRNA miR-155 represent a candidate pathogenic factor in chronic B-lymphocytic leukemia (B-CLL). In this study, we present evidence that MYB (v-myb myeloblastosis viral oncogene homolog) is overexpressed in a subset of B-CLL patients. MYB physically associates with the promoter of miR-155 host gene (MIR155HG, also known as BIC, B-cell integration cluster) and stimulates its transcription. This coincides with the hypermethylated histone H3K4 residue and spread hyperacetylation of H3K9 at MIR155HG promoter. Our data provide evidence of oncogenic activities of MYB in B-CLL that include its stimulatory role in MIR155HG transcription.

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