Type I iodothyronine 5’-deiodinase mRNA and activity is increased in adipose tissue of obese subjects

• Authors: ORTEGA F. J.; JÍLKOVÁ Z. M.; MORENO-NAVARRETE J. M.; PAVELKA Stanislav; RODRIGUEZ-HERMOSA J. I.; KOPECKÝ Jan; FERNÁNDEZ-REAL J. M.
• Year of publication: 2012
• Type: Article in Periodical
• Magazine / Source: International Journal of Obesity
• MU Faculty or unit: Central European Institute of Technology
• Web: http://www.nature.com/ijo/journal/v36/n2/full/ijo2011101a.html
• Doi: http://dx.doi.org/10.1038/ijo.2011.101
• Field: Endocrinology, diabetology, metabolism, nutrition
• Keywords: Adipose tissue; thyroid hormones; deiodinases; tissue expression; enzyme activity
• Description: Expression of the genes for type I iodothyronine 5'-deiodinase (D1), leptin (LEP) and stearoyl-CoA desaturase 1 (SCD-1) was evaluated in omental (OM) and subcutaneous (SC) fat using a cohort of 70 humans. Activities of iodothyronine deiodinases (D1, D2 and D3) were assessed in a randomly selected subpopulation of 19 subjects.

Related projects

• Proteins in metabolism and interaction of organisms with the environment