Publication details

Synergy testing of biofilm forming Enterobacteriaceae

Authors

ČERNOHORSKÁ Lenka VOTAVA Miroslav

Year of publication 2011
Type Conference abstract
MU Faculty or unit

Faculty of Medicine

Citation
Description Six wilde-type strains of Enterobacteriaceae able to form a biofilm were used. After biofilm detection with modified Christensen method, 24-hours old biofilm in trypticase soy broth medium on 96-well polystyren microtiter plates was prepared. Eight antibiotics, namely cefotaxim, ceftazidim, cefoperazon, cefepim, netilmicin, amikacin, tobramycin, ciprofloxacin, individually and in combinations (netilmicin + ciprofloxacin, cefoperazon + ciprofloxacin, cefoperazon + netilmicin, cefepim + tobramycin, cefotaxim + amikacin, cefotaxim + tobramycin, cefotaxim + netilmicin, ceftazidim + amikacin, ceftazidim + netilmicin, cefepim + amikacin) were tested. Minimum biofilm inhibitory concentration (MBIC) and fractionate inhibitory concentration (FBIC) were determined. The combinations were classified as synergistic, partially synergistic, indifferent, or antagonistic.
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