Publication details

Enhancement of psychostimulant effect and development of behavioural sensitisation to methamphetamine in mice by combined treatment with piracetam

Authors

MÁCHALOVÁ Alena ŠLAIS Karel VRŠKOVÁ Dagmar ŠULCOVÁ Alexandra

Year of publication 2011
Type Article in Periodical
Magazine / Source Activitas Nervosa Superior Rediviva
MU Faculty or unit

Faculty of Medicine

Citation
Field Pharmacology and pharmaceutical chemistry
Keywords methamphetamine; piracetam; behavioural sensitisation; mice; open field test
Description Piracetam in our experiment enhanced acute effects of methamphetamine as well as development of sensitisation to its stimulatory effects. Background of these pharmacological drug-drug interactions remains unclear. Although clinically piracetam itself shows minimal adverse effects and toxicity, its combination with methamphetamine could worsen the negative drug abuse consequences.
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