Publication details
Porovnání odhadů glomerulární filtrace ze sérových hladin cystatinu C a enzymaticky stanoveného kreatininu
| Title in English | A comparison between glomerular filtration rates estimated by means of serum cystatin C and those through creatinine determined enzymatically |
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| Authors | |
| Year of publication | 2011 |
| Type | Article in Periodical |
| Magazine / Source | Klinická biochemie a metabolismus |
| MU Faculty or unit | |
| Citation | |
| Field | Biochemistry |
| Keywords | cystatin C; creatinine; glomerular filtration |
| Description | The aim of the study was to compare the results of estimating glomerular filtration (GF) obtained from creatinine, based on the 4-variable MDRD equation and the Lund-Malmö equation, with the results of glomerular filtration estimates obtained from cystatin C based on the Grubb equation. Settings: Department of Clinical Biochemistry St. Anne’s University Hospital Brno. Single samples were taken from a set of 449 patients at the nephrology outpatients’ department, in which both serum creatinine and cystatin C concentration were analysed. Differences between GF estimates calculated by Grubb and MDRD equations and between GF estimates calculated by Grubb and Lund-Malmö equations were tested. The null hypothesis was that the mean difference between compared GF estimates was statistically significantly different from zero. The calculated estimates of GF were evaluated by paired samples t-test and by variance ratio test (F-test). Results: In the groups of men and women with GF 1.0 ml/s calculated by Grubb equation, the results were in better agreement with estimates of GF obtained from the Lund-Malmö equation (p > 0.23) than with estimates of GF obtained from the MDRD equation. Further, in groups of men and women with GF 0.8–1.2 ml/s calculated by Grubb equation, results were in better agreement with GF obtained from the Lund-Malmö equation (p = 0.448) than with GF results obtained from the MDRD equation (p = 0.0015). In groups of men and women with GF > 1.0 ml/s (Grubb equation) these estimates were in better agreement with those obtained from the MDRD equation than results obtained from the Lund-Malmö equation. In the threshold-to-reduced interval values for GF estimates calculated by Grubb equation, results were in better agreement with estimates calculated by the Lund-Malmö equation than with those calculated by the MDRD equation. |