Publication details
Lack of association between the Val158Met catechol-O-methyltransferase gene polymorphism and methamphetamine dependence
| Authors | |
|---|---|
| Year of publication | 2011 |
| Type | Article in Periodical |
| Magazine / Source | Neuroendocrinology Letters |
| MU Faculty or unit | |
| Citation | |
| Field | Psychiatry, sexuology |
| Keywords | methamphetamine dependence; Val158Met catechol-O-methyltransferase polymorphism; population-based genetic association study; family-based genetic association study; psychotic disorder |
| Description | We did not find any significant association between the Val158Met catechol-O-methyltransferase gene polymorphism and methamphetamine dependence using the population-based or family-based design (p=0.41–0.66; Chi-Square Test or UNPHASED program, Version 3.1.4, respectively). We found a trend toward a statistically significant difference between the Val allele carriers and Met/Met homozygotes in the frequence of psychotic symptoms induced by methamphetamine (more frequent in Val carriers; p=0.062; Chi-Square Test). |
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