Bilateral elevation of TNFa and IL-6 mRNAs in dorsal root ganglia alongside neuroaxis following unilateral nerve injury

• Authors: BRÁZDA Václav; KLUSÁKOVÁ Ilona; HRADILOVÁ SVÍŽENSKÁ Ivana; DUBOVÝ Petr
• Year of publication: 2011
• Type: Conference abstract
• MU Faculty or unit: Faculty of Medicine
• Description: Cytokines are injury-induced inflammatory mediators that contribute to both induction and maintenance of neuropathic pain. We used in situ hybridization and quanitative RT-PCR to provide evidence that unilateral chronic constriction injury (CCI) of the sciatic nerve induces synthesis of TNFa and IL-6 in DRG of different spinal cord segments alongside neuroaxis.

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