Multiple Myeloma Associated IgA Pemphigus: Treatment With Bortezomib- and Lenalidomide-Based Regimen

• Authors: SZTURZ Petr; ADAM Zdeněk; KLINCOVÁ Mária; FEIT Josef; KREJČÍ Marta; POUR Luděk; ZAHRADOVÁ Lenka; VAŠKŮ Vladimír; HÁJEK Roman; MAYER Jiří
• Year of publication: 2011
• Type: Article in Periodical
• Magazine / Source: Clinical Lymphoma, Myeloma & Leukemia
• MU Faculty or unit: Faculty of Medicine
• Doi: http://dx.doi.org/10.1016/j.clml.2011.06.014
• Field: Oncology and hematology
• Keywords: Autoimmunity; Bortezomib; IgA pemphigus; Lenalidomide; Multiple myeloma; Paraproteinemia
• Description: Generally, monoclonal immunoglobulins do not bind an autologous antigen, except for some cases, when it causes immune damage to body’s own tissues. Vesiculopustulous dermatitis associated with immunoglobulin (Ig) A deposition in the epidermis represents an autoimmune skin manifestation of monoclonal gammopathy. It is commonly referred to as subcorneal pustular dermatosis type of IgA pemphigus.1 In our previous work, we reported on complete and long-term remission of multiple myeloma associated IgA pemphigus after treatment with a bortezomib (Velcade) based regimen.2 In this work, to our knowledge, we are the first to publish a convincing clinical remission and excellent drug tolerance of a subsequent lenalidomide (Revlimid) based regimen used in the same patient for management of the relapsed disease.

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• University Research Centre - Czech Myeloma Group
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• Úloha mitotické disrupce v B lymfocytech u mnohočetného myelomu