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Antibiotická profylaxe u hematoonkologických nemocných - doporučení odborníků s podporou CELL, ČHS a ČOS ČLS JEP, S.CH.S. SLS
Title in English | Antibiotic prophylaxis in hematooncological patients - expert recommendation with the support of CELL, CHS a COS CLS JEP, S.CH.S. SLS |
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Authors | |
Year of publication | 2011 |
Type | Article in Periodical |
Magazine / Source | Postgraduální medicína |
MU Faculty or unit | |
Citation | |
Field | Oncology and hematology |
Keywords | antibacterial prophylaxis; fluoroquinolone; febrile neutropenia; acute leukemia; hematopoietic stem cell transplantation |
Description | Bacterial infections are potentially life-threatening complication in patients with febrile neutropenia (FN) after anticancer chemotherapy. Randomized controlled trials on fluoroquinolone (FQ) prophylaxis provided the evidence of usefulness of such an approach in reducing the rate of febrile episodes, the rate of microbiologically documented infections, the rate of Gram-negative and Gram-positive infections, and meta-analyses proved the influence on reducing all-cause and infection-related mortality. Between the most risky patients ("high risk"), to whom prophylaxis brings the highest benefit, are those with expected long lasting (more than 7 days) and profound absolute granulocytopenia (under 0,1), seen mainly in patients with acute leukemia (AL) and in hematopoietic stem cell transplant (HSCT)recipients. |