Publication details

Antibiotická profylaxe u hematoonkologických nemocných - doporučení odborníků s podporou CELL, ČHS a ČOS ČLS JEP, S.CH.S. SLS

Title in English Antibiotic prophylaxis in hematooncological patients - expert recommendation with the support of CELL, CHS a COS CLS JEP, S.CH.S. SLS
Authors

HABER Jan CETKOVSKÝ Petr RÁČIL Zdeněk DRGOŇA Luboš KOUBA Michal ŽÁK Pavel SEDLÁČEK Petr ŠTĚRBA Jaroslav FABER Edgar ADÁMKOVÁ Václava TÓTHOVÁ Elena KOLÁŘ Milan KOCMANOVÁ Iva MALLÁTOVÁ Naďa NYČ Otakar MAYER Jiří

Year of publication 2011
Type Article in Periodical
Magazine / Source Postgraduální medicína
MU Faculty or unit

Faculty of Medicine

Citation
Field Oncology and hematology
Keywords antibacterial prophylaxis; fluoroquinolone; febrile neutropenia; acute leukemia; hematopoietic stem cell transplantation
Description Bacterial infections are potentially life-threatening complication in patients with febrile neutropenia (FN) after anticancer chemotherapy. Randomized controlled trials on fluoroquinolone (FQ) prophylaxis provided the evidence of usefulness of such an approach in reducing the rate of febrile episodes, the rate of microbiologically documented infections, the rate of Gram-negative and Gram-positive infections, and meta-analyses proved the influence on reducing all-cause and infection-related mortality. Between the most risky patients ("high risk"), to whom prophylaxis brings the highest benefit, are those with expected long lasting (more than 7 days) and profound absolute granulocytopenia (under 0,1), seen mainly in patients with acute leukemia (AL) and in hematopoietic stem cell transplant (HSCT)recipients.

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