Publication details
Genetická variabilita v géne pro eotaxin u atopickej dermatitidy
| Title in English | Genetic variability eotaxin gen in atopic dermatitis |
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| Authors | |
| Year of publication | 2011 |
| Type | Conference abstract |
| MU Faculty or unit | |
| Citation | |
| Description | Eotaxin may play an important role in atopic dermatitis (AD) as a potent immunomodulatory agent. In this study, three single-nucleotide polymorphisms (-426C-T, -384A-G and 67G-A) of the eotaxin gene were associated with some phenotypes (genotype-phenotype study) of the AD patients. Significant differences were observed in genotype frequency of the 384A-G polymorphisms between AD patients with and without some complex disease beside atopy/allergy. Similarly, CC and TT genotypes of -426C-T polymorphisms were more frequent in AD patients with positive family history of atopy. No significant associations of evaluated phenotypes with 67G-A were observed. Detection of eotaxin gene polymorphisms in adult patients with atopic dermatitis seems to be a promising way form finding of clinically valid gene biomarkers for the disease. |