Publication details
Paramutation of tobacco transgenes by small RNA-mediated transcriptional gene silencing
| Authors | |
|---|---|
| Year of publication | 2011 |
| Type | Article in Periodical |
| Magazine / Source | Epigenetics |
| MU Faculty or unit | |
| Citation | |
| Doi | http://dx.doi.org/10.4161/epi.6.5.15764 |
| Field | Genetics and molecular biology |
| Keywords | transcriptional gene silencing; transgene epialleles; DNA methylation; small RNA |
| Description | It has been well established that trans-acting small RNAs guide promoter methylation leading to its inactivation and gene silencing at the transcriptional level (TGS).These features contrast with a non-methylated single copy transgenic locus that required several generations of contact with RNA silencing molecules to become imprinted in a stable epiallele. |
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