Publication details

Moving Forward with Metronomic Chemotherapy: Meeting Report of the 2nd International Workshop on Metronomic and Anti-Angiogenic Chemotherapy in Paediatric Oncology

Authors

PASQUIER Eddy KIERAN Mark W. ŠTĚRBA Jaroslav SHAKED Yuval BARUCHEL Sylvain OBERLIN Odile KIVIVUORI Maria Sanna PEYRL Andreas DIAWARRA Mamouna CASANOVA Michaela ZACHAROULIS Stergios VASSAL Gilles BERTHOLD Franck VERSCHUUR Arnauld ANDRE Nicolas

Year of publication 2011
Type Article in Periodical
Magazine / Source TRANSLATIONAL ONCOLOGY
MU Faculty or unit

Faculty of Medicine

Citation
Doi http://dx.doi.org/10.1593/tlo.11124
Field Oncology and hematology
Keywords ENDOTHELIAL PROGENITOR CELLS; SOLID TUMORS; ORAL ETOPOSIDE; BRAIN-TUMORS; ANTIANGIOGENIC THERAPY; DOSE CYCLOPHOSPHAMIDE; BREAST-CANCER; CHILDREN; RECURRENT; FUTURE
Description Metronomic chemotherapy, which is defined by the frequent, repetitive administration of chemotherapeutic drugs at relatively low doses, and without prolonged drug-free break, is an emerging strategy to fight cancer. Initially thought to act by targeting tumor angiogenesis, additional mechanisms have been recently unveiled, and metronomic chemotherapy is now considered to represent a form of multitargeted therapy. Despite representing a genuine alternative for advanced and/or high-risk cancer therapy, the development of metronomic approaches in pediatric oncology still in the early stage. The few numbers of large-scale state-of-the-art clinical trials, issues regarding terminology and the limited understanding of the complex and intertwined mechanisms of action of metronomic treatments have limited progress in this important field of research. On March 18 and 19, 2010, the 2nd International Workshop on Metronomic and Anti-Angiogenic Chemotherapy in Paediatric Oncology was held in Marseille, France, and brought together clinicians, basic scientists, physician-scientists, trainees, and students from all around the world. The main aim of this international meeting was to provide a unique forum to 1) reflect on the major advances that have been made in this field of research since its creation, 2) communicate results from the most recent clinical trials and preclinical studies, 3) discuss the current and future challenges of the field, and 4) set forth a solid framework for future collaborative biologic and clinical studies. The present report documents the main preclinical and clinical data that were presented in the keynote and best abstract sessions and delivers the key messages from the meeting.

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