Clinical correlations of miR-21 expression in colorectal cancer patients and effects of its inhibition on DLD1 colon cancer cells

• Authors: FALTEJSKOVÁ Petra; BEŠŠE Andrej; ŠEVČÍKOVÁ Sabina; KUBICZKOVÁ Lenka; SVOBODA Marek; ŠMARDA Jan; KISS Igor; VYZULA Rostislav; SLABÝ Ondřej
• Year of publication: 2012
• Type: Article in Periodical
• Magazine / Source: International Journal of Colorectal Disease
• MU Faculty or unit: Central European Institute of Technology
• Web: http://link.springer.com/article/10.1007%2Fs00384-012-1461-3
• Doi: http://dx.doi.org/10.1007/s00384-012-1461-3
• Field: Oncology and hematology
• Keywords: miR-21; colorectal cancer; DLD-1; 5-FU; SN38; L-OHP; sensitivity; apoptosis; migration
• Description: MicroRNA-21 (miR-21) is one of the miRNAs that are frequently and highly overexpressed in tumor tissue of colorectal cancer patients. We confirmed over-expression of miR-21 in colorectal cancer patients and its correlation with advanced disease and shorter overall survival. Our results suggest that it is increased migration activity of colon cancer cells over-expressing miR-21 that can be responsible for these effects.

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