Identification and functional screening of microRNAs highly deregulated in colorectal cancer

• Authors: FALTEJSKOVÁ Petra; SVOBODA Marek; ŠRŮTOVÁ Klára; MLČOCHOVÁ Jitka; BEŠŠE Andrej; NEKVINDOVÁ Jana; RADOVÁ Lenka; FABIAN Pavel; SLABÁ Kateřina; KISS Igor; VYZULA Rostislav; SLABÝ Ondřej
• Year of publication: 2012
• Type: Article in Periodical
• Magazine / Source: Journal of Cellular and Molecular Medicine
• MU Faculty or unit: Central European Institute of Technology

Web

• http://onlinelibrary.wiley.com/doi/10.1111/j.1582-4934.2012.01579.x/pdf
• http://www.ncbi.nlm.nih.gov/pubmed/22469014

• Doi: http://dx.doi.org/10.1111/j.1582-4934.2012.01579.x
• Field: Oncology and hematology
• Keywords: apoptosis; colorectal cancer; expression profilin; microRNA; migration
• Description: The aim of this study was to determine an expression profile of 667 miRNAs in CRC patients and paired non-tumoral tissues. We have identified 42 differentially expressed miRNAs and we have chosen 5 of them for further validation on an independent cohort of 125 CRC patients and in vitro analyses. Our results indicate that miR-378, miR-375, miR-422a and miR-215 play an important role in CRC as tumor suppressors, whereas miR-135b functions as an oncogene and all these miRNAs significantly contribute to the CRC pathogenesis.

Related projects

• CEITEC - Central European Institute of Technology