Publication details
MicroRNAs and their target gene networks in renal cell carcinoma
| Authors | |
|---|---|
| Year of publication | 2011 |
| Type | Article in Periodical |
| Magazine / Source | Biochem Biophys Res Commun |
| MU Faculty or unit | |
| Citation | |
| Web | http://www.sciencedirect.com/science/article/pii/S0006291X11000386 |
| Doi | http://dx.doi.org/10.1016/j.bbrc.2011.01.019 |
| Field | Oncology and hematology |
| Keywords | MicroRNA; Renal cell carcinoma; Hypoxia; Epithelial-mesenchymal transition; Proliferation; Apoptosis |
| Description | MiRNAs are related to the processes of cell proliferation, apoptosis, angiogenesis, invasion, and metastasis in RCC. MiRNAs expression profiles are associated with several RCC-specific genetic alterations. It has been well documented that several miRNAs are downstream effector molecules of the HIF-induced hypoxia response. MiR-200 family is linked to epithelial-mesenchymal transition which is one of the most significant pathogenetic mechanism in RCC. Mechanistic studies in RCC have provided the rationale of using miRNAs as potential therapeutic targets. |
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