Publication details

Circulating miR-378 and miR-451 in serum are potential biomarkers for renal cell carcinoma

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Authors

RÉDOVÁ Martina POPRACH Alexandr NEKVINDOVÁ Jana ILIEV Robert RADOVÁ Lenka LAKOMÝ Radek SVOBODA Marek VYZULA Rostislav SLABÝ Ondřej

Year of publication 2012
Type Article in Periodical
Magazine / Source Journal of Translational Medicine
MU Faculty or unit

Central European Institute of Technology

Citation
web http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3340316/?tool=pubmed
Doi http://dx.doi.org/10.1186/1479-5876-10-55
Field Oncology and hematology
Keywords Renal cell carcinoma; MicroRNA; Serum; Biomarker
Description There is no standard serum biomarker used for diagnosis or early detection of recurrence for renal cell carcinoma (RCC) patients. MicroRNAs (miRNAs) are abundant and highly stable in blood serum, and have been recently described as powerful circulating biomarkers in a wide range of solid cancers. Our aim was to identify miRNA signature that can distinguish the blood serum of RCC patients and matched healthy controls and validate identified miRNAs as potential biomarkers for RCC.
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