Breast cancer suppressor candidate-1 (BCSC-1) is a melanoma tumor suppressor that down regulates MITF

• Authors: ANGHEL Silvia I.; CORREA-ROCHAL Rafael; BUDINSKÁ Eva; BOLIGANL Kayluz F.; ABRAHAM Shahnaz; COLOMBETTI Sara; FONTAO Lionel; MARIOTTI Agnese; RIMOLDI Donata; GHANEM Ghanem E.; FISHER David E.; LÉVY Frederic; DELORENZI Mauro; PIGUET Vincent
• Year of publication: 2012
• Type: Article in Periodical
• Magazine / Source: Pigment Cell & Melanoma Research
• MU Faculty or unit: Faculty of Medicine
• Doi: http://dx.doi.org/10.1111/j.1755-148X.2012.01018.x
• Field: Oncology and hematology
• Keywords: human; melanoma; potential biomarker; BCSC-1; tumor suppressor; MITF; proliferation

Attached files

• anghel_PigCellMelanRes.pdf

• Description: Understanding the molecular aberrations involved in the development and progression of metastatic melanoma (MM) is essential for a better diagnosis and targeted therapy. We identified breast cancer suppressor candidate-1 (BCSC-1) as a novel tumor suppressor in melanoma. BCSC-1 expression is decreased in human MM, and its ectopic expression in MMderived cell lines blocks tumor formation in vivo and melanoma cell proliferation in vitro while increasing cell migration. We demonstrate that BCSC-1 binds to Sox10, which down regulates MITF, and results in a switch of melanoma cells from a proliferative to a migratory phenotype. In conclusion, we have identified BCSC-1 as a tumor suppressor in melanoma and as a novel regulator of the MITF pathway.