Publication details
Circulating osteoprotegerin and Dickkopf-1 changed significantly after surgical aortic valve replacement but remained without any significant differences after transcatheter aortic valve implantation
| Authors | |
|---|---|
| Year of publication | 2012 |
| Type | Article in Periodical |
| Magazine / Source | International Journal of Cardiology |
| MU Faculty or unit | |
| Citation | |
| Doi | http://dx.doi.org/10.1016/j.ijcard.2012.04.115 |
| Field | Cardiovascular diseases incl. cardiosurgery |
| Keywords | Calcified aortic valve stenosis; RANKL/OPG/Dkk-1; Aortic valve replacement; Transcatheter aortic valve implantation |
| Attached files | |
| Description | Non-rheumatic, calcified aortic valve stenosis (CAS) is the most frequent valvular heart disease in adults, and carries substantial morbidity and mortality. Thus, aortic valve replacement is the most commonly performed valve intervention in the adult population. The main pathognomonic sign of valve degeneration (both – native and bioprosthesis) is progressive valve calcification [1]. The presence of aortic valve calcium in patients with asymptomatic mild or moderate CAS has been recognized as the single most significant predictor of clinical progression. |