Publication details
BAFF Levels Are Elevated in Paediatric Patients With Acute Lymphoblastic Leukaemia Compared to Other B-Lineage Neoplasms
| Authors | |
|---|---|
| Year of publication | 2012 |
| Type | Article in Periodical |
| Magazine / Source | Journal of Hematology |
| MU Faculty or unit | |
| Citation | |
| Doi | http://dx.doi.org/10.4021/jh104e |
| Field | Oncology and hematology |
| Keywords | B-cell activating factor; Acute lymphoblastic leukaemia; B-cell lymphoma; Paediatric |
| Attached files | |
| Description | There is emerging evidence that B-lineage neoplasms have aberrant expression of B-cell activating factor (BAFF) that enables the B cells to escape apoptosis. The aim of the study therefore was to investigate circulating levels of BAFF in paediatric malignancies related to B-cell growth, i.e. B-cell acute lymphoblastic leukaemia (B-ALL) and B-lineage lymphomas. We observed significant differences in circulating levels of BAFF between the B-ALL patients and B-cell lymphoma patients (Bcp-ALL: 7764 plus-minus 6329 pg/ml, Bcell lymphoma: 2675 plus-minus 1544 pg/ml; P = 0.0268), the circulating levels of BAFF being substantially higher in B-ALL cases. |