Publication details
Trabekulektomie s mitomycinem C v léčbě dětského glaukomu
| Title in English | Trabeculectomy with mitomycin C in the treatment of pediatric glaucoma |
|---|---|
| Authors | |
| Year of publication | 2012 |
| Type | Article in Periodical |
| Magazine / Source | Folia strabologica et neuroophthalmologica |
| MU Faculty or unit | |
| Citation | |
| Field | ORL, ophthalmology, stomatology |
| Keywords | trabeculectomy with mitomycin C; childhood glaucoma; pediatric glaucoma |
| Description | Purpose: To evaluate a long term efficacy and safety of trabeculectomy (TE) with adjunctive intraoperative use of mitomycin-C (MMC) in pediatric patients with primary and secondary glaucomas, and to identify risk factors for failure of this technique. Results: The 12-, 24-, 36-, 48- and 60- month life-table cumulative probabilities of success ratefor IOP control were 79%,71%, 65%, 62% and 58% respectively. Multivariate regression analysis determined these factors as significantly increased risk for failure: age of less than 1 year at time of surgery, aphakia, aniridia, anterior segment dysgenesis and gipsy race.There was no difference in cumulative success rate during follow up between primary and secondary glaucoma patients. A total of 28 eyes (35.9% were classified as failures. Conclusions:Our study demonstrates that TE s MMC is an effective treatment for many pediatric glaucomas in which goniotomy, trabeculotomy or both have failed.Bleb–related endophthalmitis is an important risk with this surgery in children. Phakic children over 1 year of age at time of surgeryhave a significantly higher probability of success than aphakic eyes in younger children. |