HMGB1 gene knockout in mouse embryonic fibroblasts results in reduced telomerase activity and telomere dysfunction

• Authors: POLANSKÁ Eva; DOBŠÁKOVÁ Zuzana; DVOŘÁČKOVÁ Martina; FAJKUS Jiří; ŠTROS Michal
• Year of publication: 2012
• Type: Article in Periodical
• Magazine / Source: Chromosoma
• MU Faculty or unit: Central European Institute of Technology
• Web: http://link.springer.com/article/10.1007%2Fs00412-012-0373-x
• Doi: http://dx.doi.org/10.1007/s00412-012-0373-x
• Field: Genetics and molecular biology
• Keywords: REPEAT AMPLIFICATION PROTOCOL; CHROMOSOMAL-PROTEIN HMG1; DNA-DAMAGE; CHROMATIN; MAINTENANCE; BINDING; EXPRESSION; COMPLEXES; GENOME; GROWTH
• Description: Telomere repeats are added onto chromosome ends by telomerase, consisting of two main core components: a catalytic protein subunit (telomerase reverse trancriptase, TERT), and an RNA subunit (telomerase RNA, TR). The ability of HMGB1 to modulate cellular activity of telomerase and to maintain telomere integrity can help to understand some aspects of the protein involvement in chromosome stability and cancer.

Related projects

• Telomeres and telomerase: transition from molecular to structural biology approach
• CEITEC - Central European Institute of Technology
• Proteiny HMGB: funkce v biologii telomer a lidských embryonálních kmenových buněk