Informace o projektu
Analýza biologicky významných molekulárních komplexů
- Kód projektu
- VS97032
- Období řešení
- 9/1997 - 12/2000
- Investor / Programový rámec / typ projektu
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Ministerstvo školství, mládeže a tělovýchovy ČR
- Posílení výzkumu na vysokých školách
- Fakulta / Pracoviště MU
- Přírodovědecká fakulta
The aim of the project is to build a laboratory focused on the study of functionally important complexes of biomacromolecules, namely those of nucleic acids and proteins, which form so called genome architecture (telomeres, centromeres, A study of the genetic heterochromatin blocks, complexes of nuclear matrix, nucleosomes). Metabolism of genetic material (replication, transcription, recombination) proceeds at these complexes and is, therefore, significantly affectedby their properties. information in its nuclear context will determine the basis of education of our postgraduate students. During the next four years, the nucleoprotein complexes will be characterised, which form indispensable functional elements of eukaryotic chromosomes - the telomeres.
Publikace
Počet publikací: 34
2001
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PCR-RFLP rapid detection and species identification of fungal pathogens in patients with febrile neutropenia
Programme and Abstract Book, rok: 2001
2000
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Analysis of the G-overhang structures on plant telomeres: evidence for two distinct telomere architectures
The Plant Journal, rok: 2000, ročník: 23, vydání: 5
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Detailed Mapping of Methylcythosine Positions at the CpG Island Surrounding tha Pa Promoter at the bcr-abl Locus in CML Patients in Two Cell Lines, K562 and BV 173
Blood Cells, Molecules and Diseases, rok: 2000, ročník: 26, vydání: 3
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DNA and Chromatin Structure of Telomere-Subtelomere Junctions in Silene latifolia
J.Biomol. Struct. Dyn., rok: 2000, ročník: 17, vydání: 6
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Homomeric Interaction Of the Mouse Rad52 Protein
J.Biomol. Struct. Dyn., rok: 2000, ročník: 17, vydání: 6
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Inhibition of plant telomerase by telomere-binding proteins from nuclei of telomerase-negatative tissues
FEBS letters : for the rapid publication of short reports in biochemistry, biophysics and molecular biology, rok: 2000, ročník: 467, vydání: 2-3
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Telomerase Activity and Expresion and Telomere Analysis in Situ in the Course of Treatment of Childhood Leukemias
Blood Cells, Molecules and Diseases, rok: 2000, ročník: 26, vydání: 5
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Telomerase activity and expression in the course of treatment of acute childhood leukemias
Miami Nature Biotechnology Short Reporřts, Volume 11m, Advances in Gene Technology: DNA, RNA and CANCER, rok: 2000
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Telomerase Activity,Expression and Telomere in situ Analysis in the Course of Treatment of Childhood Leukemias
J.Biomol. Struct. Dyn., rok: 2000, ročník: 17, vydání: 6
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Telomere-binding Proteins from Nuclei of Telomerase-Negative Tissues Inhibit Plant Telomerase (invited lecture)
J.Biomol. Struct. Dyn., rok: 2000, ročník: 17, vydání: 6